Congratulations to the fellows, coordinators, and others at SPIRIT sites who are leaving us for the next stage in their careers and training! Thank you, all, for the hard work and the many contributions you made to the NIH StrokeNet trials.

SISTER First Enrollment. Site PI James Giles, MD, and Lead Coordinator Rachel Kitagawa enrolled their first SISTER patient at Yale New Haven Hospital on May 2, 2024! This was also the first subject randomized into the SISTER study overall! Many were involved in making this happen, so thank you to everyone!

CAPTIVA-MRI is open for enrollments. Adam de Havenon, MD, (Yale) is the lead principal investigator for CAPTIVA-MRI, an observational multimodal magnetic resonance imaging (MRI) study that is ancillary to the CAPTIVA trial. CAPTIVA-MRI will have 30 sites with the goal of enrolling 300 subjects. One of those sites, North Shore University Hospital (Site PI Rohan Arora, MD, and Coordinator Kirendra Pasram), opened to enrollment on June 10, 2024 and enrolled its first and the study's second subject on June 19, 2024.

StrokeNet 2025-2026 Fellowship Announcement: The SPIRIT Regional Coordinating Center is accepting applications for the 2025-2026 StrokeNet SPIRIT Fellowship. Eligible candidates include residents, fellows, post-doctoral associates, nurses, and junior faculty from any discipline within the SPIRIT institutions of Hartford Healthcare, Northwell Health, Brown University/Rhode Island Hospital, and Yale University. Applications are due September 20, 2024. The fellowship starts July 1, 2025.

Save the Date: StrokeNet Fall Network Meeting; Monday, September 30, 2024, 8:30 a.m. - 4 p.m. EST; Atlanta Airport Marriott; Attendance is limited, though a virtual option should be offered.

Save the Date: SPIRIT StrokeNet Fall Meeting; Wednesday, October 30, 2024, 8:30 a.m. - 3 p.m.; This in-person meeting will be held at the Madison Beach Hotel in Madison, Conn.

Save the Date: SPIRIT StrokeNet Coordinator/Manager Quarterly Meeting; Tuesday, September 10, 2024, 11:30 a.m. - 12 p.m.; Virtual; Contact Ruth Arnold (ruth.arnold@yale.edu) for the Outlook Appointment.

It's That Time of Year! As team transitions occur, make sure that you are updating Delegations of Authority and getting new people trained up as soon as possible to avoid summer breaks in consenting and enrollments. The following two websites provide more information:

Useful Information! The new Clinical Research Professional Education/Training Core Committee has updated the Education section of the NIH StrokeNet website. Look for the April 24, 2024 Coordinator Webinar, "Practical Guide to Training on the Process of Using e-Consent," the May 22, 2024 Coordinator Webinar, "Source Documentation: Helpful Tips and Tricks," and the six NIH StrokeNet stroke Education lectures, and lots more!

Useful Information - Continued! Check out the StrokeNet: SPIRIT website! Look here for an overview of how your site and the SPIRIT RCC fits within StrokeNet, which trials are being run at which SPIRIT sites, and more information about he SPIRIT Fellowship, past SPIRIT conferences, and past SPIRIT newsletter issues.

• April 2024: North Shore University Hospital (Site PI Rohan Arora, MD, and Coordinator Kirendra Pasram) was recognized for reaching a new milestone in March - its 40th subject randomization into Sleep SMART (NIH StrokeNet First Friday Update, April 5, 2024)! Astounding!
• April 2024: Yale New Haven Hospital (Site PI Carlos Mena, MD, and Coordinator Juan Carmona) continues to ride the crest with three CREST-2 patients randomized in March (NIH StrokeNet First Friday Update, April 5, 2024)!
• April 2024: A round of applause, please! Since the previous newsletter, North Shore University Hospital (Site PI Rohan Arora, MD, and Coordinator Kirendra Pasram) randomized three patients into CAPTIVA (NIH StrokeNet First Friday Update, April 5, 2024)!
• May 2024: Both Yale New Haven Hospital (Site PI Carlos Mena, MD, and Coordinator Juan Carmona) and The Miriam Hospital (Site PI Peter Soukas, MD, and Coordinator Lina Felix) randomized subjects into CREST-2 in April. For Yale, the count was eight!!! (NIH StrokeNet First Friday Update, May 3, 2024)!
• May 2024: The Miriam Hospital (Site PI Peter Soukas, MD, and Coordinator Lina Felix) and Yale New Haven Hospital (Site PI Carlos Mena, MD, and Coordinator Juan Carmona) randomized subjects into CREST-H in April. Five patients were enrolled by Yale! (NIH StrokeNet First Friday Update, May 3, 2024)!
• May 2024: North Shore University Hospital (Site PI Rohan Arora, MD, and Coordinator Kirendra Pasram), randomized an ASPIRE patient in April (NIH StrokeNet First Friday Update, May 3, 2024)!
• June 2024: Yale Site PI James Giles, MD, Lead Coordinator Rachel Kitagawa, and the SISTER team were acknowledged for randomizing their first SISTER subject less than one month after Yale was released to enroll (SISTER Monthly Newsletter, June 2024).
  

It should come as no surprise to anyone within the SPIRIT RCC how sensational recruitment efforts have been at North Shore University Hospital! In the three months prior to June 20, 2024, North Shore Hospital, with the leadership of Site PI Rohan Arora, MD, and Coordinator Kirendra Pasram, had 12 enrollments across five StrokeNet trials: seven into CAPTIVA, one into CAPTIVA-MRI, three into Sleep SMART, and one into ASPIRE. Their efforts put North Shore in the top echelon for both CAPTIVA (rank of 4 with 21 enrollments as of June 19, 2024) and Sleep SMART (rank of 6 with 42 enrollmens as of June 19, 2024). They are definitely doing something right!

Pictured left to right: Coordinator Kirendra Pasram and Dr. Arora

• ASPIRE - (Consents = 42; Randomized = 24)
  • Hartford - 3 consented, 1 randomized
  • North Shore - 9 consented, 7 randomized
  • Rhode Island - 5 consented, 3 randomized
  • Yale - 25 consented, 13 randomized
• CAPTIVA - (Consents = 30; Randomized = 30) and CAPTIVA-MRI (Randomized = 1)
  • Hartford - 3 consented, 3 randomized
  • North Shore - 21 consented, 21 randomized; plus 1 CAPTIVA-MRI
  • Rhode Island - 2 consented, 2 randomized
  • Yale - 4 consented, 4 randomized
• I-ACQUIRE - (Consented = 11; Randomized = 9)
  • Yale - 8 consented, 6 randomized
  • Rhode Island site - 3 consented, 3 randomized
• SATURN - (Randomized = 25)
  • Hartford - 9
  • South Shore - 0
  • Staten Island - 1
  • Rhode Island - 9
  • Yale - 6
• SATURN-MRI - (Randomized = 11)
  • Hartford - 5
  • South Shore - 0
  • Staten Island - 0
  • Rhode Island - 3
  • Yale - 3
• SLEEPSMART - (Consents = 255; Randomized = 83)
  • Hartford Hospital - 41 consented, 24 randomized
  • North Shore - 156 consented, 42 randomized
  • Staten Island - 9 consented, 1 randomized
  • Yale - 49 consented, 16 randomized

June 15, 2023 – June 20, 2024, N=66

See the StrokeNet: SPIRIT website for more publications.

Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association. Yaghi S, Engelter S, Del Brutto VJ, Field TS, Jadhav AP, Kicielinski K, Madsen TE, Mistry EA, Salehi Omran S, Pandey A, Raz E; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Peripheral Vascular Disease. Stroke. 2024 Mar;55(3):e91-e106. doi: 10.1161/STR.0000000000000457. Epub 2024 Feb 1.PMID: 38299330 Free article. Review.

Addressing disparities in the global epidemiology of stroke. Prust ML, Forman R, Ovbiagele B. Nat Rev Neurol. 2024 Apr;20(4):207-221. doi: 10.1038/s41582-023-00921-z. Epub 2024 Jan 16.PMID: 38228908 Review.

In mild ischemic stroke or high-risk TIA, DAPT started <72 h after onset reduced new stroke and increased bleeding at 90 d. Alberts MJ. Ann Intern Med. 2024 May;177(5):JC53. doi: 10.7326/J24-0029. Epub 2024 May 7. PMID: 38710076

Quantitative magnetic resonance angiography as an alternative imaging technique in the assessment of cerebral vasospasm after subarachnoid hemorrhage. Shah KA, White TG, Teron I, Turpin J, Dehdashti AR, Temes RE, Black K, Woo HH. Interv Neuroradiol. 2024 Apr;30(2):271-279. doi: 10.1177/15910199221138167. Epub 2022 Nov 10.PMID: 36357992